Magnesium L-Threonate - Mental Health

  • Magnesium L-Threonate Enhances Brain Magnesium Levels: Scientific studies have demonstrated that Magnesium L-Threonate effectively crosses the blood-brain barrier, leading to elevated magnesium levels in the brain. This increase has been associated with enhanced synaptic plasticity and cognitive function, suggesting potential benefits for mental clarity and memory. [PubMed]

  • Rapid Recovery from Major Depression Using Magnesium Treatment: A case series published in Medical Hypotheses reported that individuals with major depression experienced significant improvements within a week of taking 125–300 mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. The study hypothesized that magnesium deficiency, potentially induced by stress and excessive dietary calcium, could be a contributing factor to major depression. [PubMed]

  • Magnesium Supplementation and Depression in Adults: A systematic review and meta-analysis published in Frontiers in Psychiatry analyzed randomized clinical trials to assess the impact of magnesium supplementation on depression scores in adults. The meta-analysis, which included seven clinical trials with a total of 325 participants, found a significant reduction in depression scores following magnesium supplementation. [Frontiers in Psychiatry]

  • Magnesium Intake and Depression Association: A cross-sectional analysis from the National Health and Nutrition Examination Survey (NHANES) examined the relationship between magnesium intake and depression in nearly 9,000 U.S. adults. The study found a significant association between very low magnesium intake and the prevalence of depression, particularly in younger adults. [James Greenblatt MD]
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